R: Derive Last Dose with User-Defined Groupings

derive_var_last_dose_grp {admiral}

R Documentation

Derive Last Dose with User-Defined Groupings

Description

Add a variable for user-defined dose grouping of the last dose to the input dataset.

Note: This is a wrapper function for the function derive_vars_last_dose().

This function is deprecated, please use derive_vars_joined() instead.

Usage

derive_var_last_dose_grp(
  dataset,
  dataset_ex,
  filter_ex = NULL,
  by_vars = exprs(STUDYID, USUBJID),
  dose_id = exprs(),
  dose_date,
  analysis_date,
  single_dose_condition = (EXDOSFRQ == "ONCE"),
  new_var,
  grp_brks,
  grp_lbls,
  include_lowest = TRUE,
  right = TRUE,
  dose_var = EXDOSE,
  traceability_vars = NULL
)

Arguments

`dataset`	Input dataset. The variables specified by the `by_vars` and `analysis_date` parameters are expected.
`dataset_ex`	Input EX dataset. The variables specified by the `by_vars`, `dose_date`, `new_vars` parameters, and source variables from `traceability_vars` parameter are expected.
`filter_ex`	Filtering condition applied to EX dataset. For example, it can be used to filter for valid dose. Defaults to NULL.
`by_vars`	Variables to join by (created by `rlang::exprs`).
`dose_id`	Variables to identify unique dose (created by `rlang::exprs`). Defaults to empty `exprs()`.
`dose_date`	The EX dose date variable. A date or date-time object is expected.
`analysis_date`	The analysis date variable. A date or date-time object is expected.
`single_dose_condition`	The condition for checking if `dataset_ex` is single dose. An error is issued if the condition is not true. Defaults to `(EXDOSFRQ == "ONCE")`.
`new_var`	The output variable defined by the user.
`grp_brks`	User supplied breaks to apply to groups. Refer to `breaks` parameter in `cut()` for details.
`grp_lbls`	User supplied labels to apply to groups. Refer to `labels` parameter in `cut()` for details.
`include_lowest`	logical, indicating if a value equal to the lowest (or highest, for right = FALSE) ‘breaks’ value should be included. Refer to `include.lowest` parameter in `cut()` for details.
`right`	Logical, indicating if the intervals should be closed on the right (and open on the left) or vice versa. Refer to `right` parameter in `cut()` for details.
`dose_var`	The source dose amount variable. Defaults to `EXDOSE`.
`traceability_vars`	A named list returned by `exprs()` listing the traceability variables, e.g. `exprs(LDOSEDOM = "EX", LDOSESEQ = EXSEQ)`. The left-hand side (names of the list elements) gives the names of the traceability variables in the returned dataset. The right-hand side (values of the list elements) gives the values of the traceability variables in the returned dataset. These can be either strings or symbols referring to existing variables.

Details

Last dose is the dose with maximum dose_date that is lower to or equal to the analysis_date per by_vars for each observation in dataset. The last dose group is then derived by user-defined grouping, which groups dose_var as specified in grp_brks, and returns grp_lbls as the values for new_var.

If dose information is aggregated (i.e. is a dosing frequency other than "ONCE" over a period defined by a start and end date) the function create_single_dose_dataset() can be used to generate single doses from aggregate dose information and satisfy single_dose_condition.

Value