sepsis {aVirtualTwins}

Clinical Trial for Sepsis desease

Description

Simulated clinical trial with two groups treatment about sepsis desease. See details.

Usage

data(sepsis)

Format

470 patients and 13 variables.

survival

binary outcome

THERAPY

1 for active treatment, 0 for control treatment

TIMFIRST

Time from first sepsis-organ fail to start drug

AGE

Patient age in years

BLLPLAT

Baseline local platelets

blSOFA

Sum of baselin sofa (cardiovascular, hematology, hepaticrenal, and respiration scores)

BLLCREAT

Base creatinine

ORGANNUM

Number of baseline organ failures

PRAPACHE

Pre-infusion apache-ii score

BLGCS

Base GLASGOW coma scale score

BLIL6

Baseline serum IL-6 concentration

BLADL

Baseline activity of daily living score

BLLBILI

Baseline local bilirubin

Details

This dataset is taken from SIDES method.

Sepsis contains simulated data on 470 subjects with a binary outcome survival, that stores survival status for patient after 28 days of treatment, value of 1 for subjects who died after 28 days and 0 otherwise. There are 11 covariates, listed below, all of which are numerical variables.

Note that contrary to the original dataset used in SIDES, missing values have been imputed by random forest (randomForest::rfImpute()). See file data-raw/sepsis.R for more details.

True subgroup is PRAPACHE <= 26 & AGE <= 49.80. NOTE: This subgroup is defined with the lower event rate (survival = 1) in treatement arm.

Source

http://biopharmnet.com/subgroup-analysis-software/