Implementing EFF-TOX and Monotone Utility Based Phase 12 Trials


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Documentation for package ‘UtilityFrailtyPH12’ version 1.0

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GetDesire Returns the desireability value of a dose.
GetOptimalUT Gives the dose to assign the next patient cohort using monotone utility based phase 12 trial.
GetPriors Returns prior dose-specific means.
RunAdaptiveEFFTOX Simulates replications from EFF-TOX phase 12 trial.
RunAdaptiveUT Simulates replications from the monotone utility based phase 12 trial.
UTEFFTOX Samples from the posterior of the utility based phase12 model.