select_mtd_gBOIN_continuous {UnifiedDoseFinding}

Select the maximum tolerated dose (MTD) for single agent trials using gBOIN design

Description

Select the maximum tolerated dose (MTD) when the trial is completed using gBOIN design (Mu et al. 2017)

Usage

select_mtd_gBOIN_continuous(target, npts, ntox)

Arguments

target

the continuous target score

npts

the number of patients enrolled at each dose level

ntox

the toxicity score at each dose level

Value

select_mtd_gBOIN_continuous() returns the selected dose

Author(s)

Chia-Wei Hsu, Haitao Pan, Rongji Mu

References

Rongji Mu, Ying Yuan, Jin Xu, Sumithra J. Mandrekar, Jun Yin: gBOIN: a unified model-assisted phase I trial design accounting for toxicity grades, and binary or continuous end points. Royal Statistical Society 2019

Examples

target <- 1.47
n <- c(3, 3, 3, 9, 0, 0)
y <- c(0.1951265, 1.5434317, 2.1967343, 13.9266838, 0, 0)
select_mtd_gBOIN_continuous(target = target, npts = n, ntox = y)