select_mtd_Ivanova_continuous {UnifiedDoseFinding}

Select the maximum tolerated dose (MTD) for single agent trials of continuous endpoint using design by Ivanova et al (2009)

Description

Select the maximum tolerated dose (MTD) when the trial is completed for continuous endpoint using design by Ivanova et al (2009)

Usage

select_mtd_Ivanova_continuous(target, c_resp, n)

Arguments

target

the target toxicity score

c_resp

list object. Each element contains continuous value for each measurement

n

the number of patients enrolled at each dose level

Value

select_mtd_Ivanova_continuous() returns a list object including: (1) dose selected (2) patients treated at each dose level

Author(s)

Chia-Wei Hsu, Haitao Pan, Rongji Mu

References

Ivanova, Anastasia, and Se Hee Kim. "Dose finding for continuous and ordinal outcomes with a monotone objective function: a unified approach." Biometrics 65, no. 1 (2009): 307-315.

Examples

target <- 1.47
c_resp <- list(c(0, 0.05475884, 0.12446843, 0.10131912),
               c(0, 0.4716962, 0.2792428, 0.3296575),
               c(0, 0.3931168, 1.6116607, 0.1642561),
               c(0, 0.9410027, 1.6021326, 1.6115235,
                 1.1735981, 2.5575655, 1.6513679, 1.4269044,
                 0.8983843, 2.2209587),
               0,
               0)
n <- c(3, 3, 3, 9, 0, 0)
select_mtd_Ivanova_continuous(target = target, c_resp = c_resp, n = n)