select_mtd_Ivanova_binary {UnifiedDoseFinding}

Select the maximum tolerated dose (MTD) of binary endpoint for single agent trials using design by Ivanova et al (2009)

Description

Select the maximum tolerated dose (MTD) when the trial is completed for binary endpoint using design by Ivanova et al (2009)

Usage

select_mtd_Ivanova_binary(target, y, n)

Arguments

target

the target toxicity rate

y

the number of toxicity patients at each dose level

n

the number of patients enrolled at each dose level

Value

select_mtd_Ivanova_binary() returns a list object including: (1) dose selected (2) patients treated at each dose level

Author(s)

Chia-Wei Hsu, Haitao Pan, Rongji Mu

References

Ivanova, Anastasia, and Se Hee Kim. "Dose finding for continuous and ordinal outcomes with a monotone objective function: a unified approach." Biometrics 65, no. 1 (2009): 307-315.

Examples

target <- 0.3
y <- c(0, 4, 0, 0, 0, 0)
n <- c(3, 15, 0, 0, 0, 0)
select_mtd_Ivanova_binary(target = target, y = y, n = n)