| next_gBOIN_continuous {UnifiedDoseFinding} | R Documentation |
Determine the dose for the next cohort of new patients for single-agent trials that aim to find a maximum tolerated dose (MTD) using gBOIN design
Description
Determine the dose for the next cohort of new patients for single-agent trials that aim to find a MTD under continuous measure using gBOIN design (Mu et al., 2017)
Usage
next_gBOIN_continuous(target, n, y, d, mu_1 = 0.6 * target, mu_2 = 1.4 * target)
Arguments
target |
the continuous target score |
n |
the number of patients enrolled at each dose level |
y |
the toxicity score at each dose level |
d |
the current dose level |
mu_1 |
the lower bound. The default value is 0.6 * target |
mu_2 |
the upper bound. The default value is 1.4 * target |
Value
next_gBOIN_continuous() returns recommended dose level for the next cohort as a numeric value under continuous measure
Author(s)
Chia-Wei Hsu, Haitao Pan, Rongji Mu
References
Mu, Rongji, Ying Yuan, Jin Xu, Sumithra J. Mandrekar, and Jun Yin. "gBOIN: a unified model-assisted phase I trial design accounting for toxicity grades, and binary or continuous end points." Journal of the Royal Statistical Society. Series C: Applied Statistics 68, no. 2 (2019): 289-308.
Examples
target <- 1.47
n <- c(3, 3, 3, 9, 0, 0)
y <- c(0.1951265, 1.5434317, 2.1967343, 13.9266838, 0, 0)
d <- 4
next_gBOIN_continuous(target = target, n = n, y = y, d = d)