next_Ivanova_binary {UnifiedDoseFinding}

Determine the dose for the next cohort of new patients of binary endpoint using design by Ivanova et al (2009)

Description

Determine the dose for the next cohort of new patients for single-agent trials of binary endpoint that aim to find a MTD using design by Ivanova et al (2009)

Usage

next_Ivanova_binary(target, eps, y, n, d)

Arguments

target

the target toxicity rate

eps

the decision criterion

y

the number of toxicity patients at each dose level

n

the number of patients enrolled at each dose level

d

the current dose level

Value

next_Ivanova_binary() returns recommended dose level for the next cohort as a numeric value

Author(s)

Chia-Wei Hsu, Haitao Pan, Rongji Mu

References

Ivanova, Anastasia, and Se Hee Kim. "Dose finding for continuous and ordinal outcomes with a monotone objective function: a unified approach." Biometrics 65, no. 1 (2009): 307-315.

Examples

target <- 0.3
eps <- 1
y <- c(0, 4, 0, 0, 0, 0)
n <- c(3, 15, 0, 0, 0, 0)
d <- 2
next_Ivanova_binary(target = target, eps = eps, y = y, n = n, d = d)