get_oc_Ivanova_continuous {UnifiedDoseFinding}

Generate operating characteristics for finding the maximum tolerated dose (MTD) of continuous endpoint using design by Ivanova et al (2009)

Description

Obtain the operating characteristics of the dose-finding design of continuous endpoint by Ivanova et al (2009)

Usage

get_oc_Ivanova_continuous(target, eps = 1, ptox, ncohort,
                          cohortsize, n.earlystop = 100,
                          ntrial, startdose = 1, seed = 100)

Arguments

target

the continuous target score

eps

the decision criterion. The default value is eps = 1

ptox

the true mean value of the continuous measure

ncohort

the number of cohorts

cohortsize

the cohort size

n.earlystop

the early stopping parameter. The default value is n.earlystop = 100

ntrial

the number of simulated trials

startdose

the starting dose level. The default value is startdose = 1

seed

the seed. The default value is seed = 100

Value

get_oc_Ivanova_continuous() returns the operating characteristics of Ivanova design as a list object, including: (1) selection percentage at each dose level (2) patients treated at each dose level

Author(s)

Chia-Wei Hsu, Fang Wang, Haitao Pan, Rongji Mu

References

Ivanova, Anastasia, and Se Hee Kim. "Dose finding for continuous and ordinal outcomes with a monotone objective function: a unified approach." Biometrics 65, no. 1 (2009): 307-315.

Examples

target <- 1.47
ptox <- c(0.11, 0.25, 0.94, 1.47, 2.38, 2.40)
ncohort <- 10
cohortsize <- 3
ntrial <- 4000
get_oc_Ivanova_continuous(target = target, ptox = ptox, ncohort = ncohort,
                          cohortsize = cohortsize, ntrial = ntrial)