analyze_gene_drug_response_asso {UCSCXenaShiny} | R Documentation |
Analyze Association between Gene (Signature) and Drug Response with CCLE Data
Description
Analyze partial correlation of gene-drug association after controlling for tissue average expression.
Usage
analyze_gene_drug_response_asso(gene_list, combine = FALSE)
Arguments
gene_list |
a gene symbol list. |
combine |
if |
Value
a data.frame
If
combine
isTRUE
, genes are combined assignature
.-
mean.diff
andmedian.diff
indicate mean and median of normalized expression difference between High IC50 cells and Low IC50 cells. The cutoff between High and Low are median IC50.
Examples
## Not run:
analyze_gene_drug_response_asso("TP53")
analyze_gene_drug_response_asso(c("TP53", "KRAS"))
analyze_gene_drug_response_asso(c("TP53", "KRAS"), combine = TRUE)
# Visualization
vis_gene_drug_response_asso("TP53")
## End(Not run)
[Package UCSCXenaShiny version 2.1.0 Index]