| updata {UBCRM} | R Documentation |
Update the CRM dataframe after new patients' collected data
Description
This function uptdates the CRM dataframe (result of the CreData routine) with new treated patients or observed DLTs.
Usage
updata(data = data, lastdose, npt, ndlt)
Arguments
data |
Dataframe to be updated. |
lastdose |
Integer representing the dose to be updated. |
npt |
Number of new treated patients. |
ndlt |
Number of DLTs among the npt patients. |
Value
Updated dataframe.
Author(s)
Benjamin Esterni, Baboukar Mane. Unite de Biostatistique et de Methodologie, Institut Paoli-Calmettes, Marseille, France.
References
O'Quigley J., Pepe M., Fisher L. (1990). Continual Reassessment Method: a practical design for Phase I clinical trials in cancer. Biometrics 46, 33-48. <https://doi.org/10.2307/2531628>
O'Quigley J., Shen LZ. (1996). Continual Reassessment Method: a likelihood approach. Biometrics 52, 673-684. <https://doi.org/10.2307/2532905>
Paoletti X., Kramar A. (2009). A comparison of model choices for the Continual Reassessment Method in phase I cancer trials. Statistics in Medecine 28, 3012-3028. <https://doi.org/10.1002/sim.3682>
Chamorey Emmanuel. (2009). Methodologie des essais de phase precoce en cancerologie: evolution des schemas et apport de la pharmacologie. These.
Garret-Mayer Elizabeth. (2006). The Continual Reassessment Method for dose-finding studies: a tutorial. Clinical Trials: 57-71. <https://doi.org/10.1191/1740774506cn134oa>
See Also
Examples
# Study initialization
data<- CreData(5,c("5 mg/m2","7 mg/m2","10 mg/m2","15 mg/m2","20 mg/m2"))
data
# Three patients are treated at the dose 1, without any observed DLT:
data<- updata(data,lastdose=1,npt=3,ndlt=0)
data