troisPtrois {UBCRM}

Dose escalation with the 3+3 design

Description

The function gives the next level to include patients following a 3+3 design. Needs an updated input dataframe with the CreData() structure.

Usage

troisPtrois(data = data, lastdose)

Arguments

data

Study dataframe with CreData() structure.

lastdose

Integer representing the last experimented dose level.

Value

nextdose

An integer representing the next recommended dose to experiment.

mtd

If reached, an integer representing the MTD.

Author(s)

Benjamin Esterni, Baboukar Mane. Unite de Biostatistique et de Methodologie, Institut Paoli-Calmettes, Marseille, France.

References

O'Quigley J., Pepe M., Fisher L. (1990). Continual Reassessment Method: a practical design for Phase I clinical trials in cancer. Biometrics 46, 33-48. <https://doi.org/10.2307/2531628>

O'Quigley J., Shen LZ. (1996). Continual Reassessment Method: a likelihood approach. Biometrics 52, 673-684. <https://doi.org/10.2307/2532905>

Paoletti X., Kramar A. (2009). A comparison of model choices for the Continual Reassessment Method in phase I cancer trials. Statistics in Medecine 28, 3012-3028. <https://doi.org/10.1002/sim.3682>

Chamorey Emmanuel. (2009). Methodologie des essais de phase precoce en cancerologie: evolution des schemas et apport de la pharmacologie. These.

Garret-Mayer Elizabeth. (2006). The Continual Reassessment Method for dose-finding studies: a tutorial. Clinical Trials: 57-71. <https://doi.org/10.1191/1740774506cn134oa>

See Also

sim3p3, ssim3p3

Examples

# Study initialization
data<- CreData(5,c("5 mg/m2","7 mg/m2","10 mg/m2","15 mg/m2","20 mg/m2"))
data

# Three patients are treated at the dose 1, without any observed DLT:
data<- updata(data,lastdose=1,npt=3,ndlt=0)
data

# 3+3 design
troisPtrois(data,lastdose=1)