| ssim3p3 {UBCRM} | R Documentation |
Simulation of n dose-escalation study with the 3+3 design
Description
The ssim3p3 function simulates n dose-escalation study with the 3+3 design and provides summarized results.
Usage
ssim3p3(truerate, n, r = 2, seed = NULL)
Arguments
truerate |
A nlevel-length vector of true rates for the DLTs. |
n |
Number of studies to simulate. |
r |
Integer, number of digits for percentages in output. |
seed |
If not empty, the seed to use for random generation. |
Value
data |
Summarized result in a "np1" view. |
norecommendation |
Percentage of studies with no recommendation for the MTD (in case of the first level is considered as toxic). |
mean.npt |
Mean number of enrolled patients. |
mean.ndlt |
Mean number of observed DLTs. |
mean.lastdose |
Mean last experimented dose level. |
Author(s)
Benjamin Esterni, Baboukar Mane. Unite de Biostatistique et de Methodologie, Institut Paoli-Calmettes, Marseille, France.
References
O'Quigley J., Pepe M., Fisher L. (1990). Continual Reassessment Method: a practical design for Phase I clinical trials in cancer. Biometrics 46, 33-48. <https://doi.org/10.2307/2531628>
O'Quigley J., Shen LZ. (1996). Continual Reassessment Method: a likelihood approach. Biometrics 52, 673-684. <https://doi.org/10.2307/2532905>
Paoletti X., Kramar A. (2009). A comparison of model choices for the Continual Reassessment Method in phase I cancer trials. Statistics in Medecine 28, 3012-3028. <https://doi.org/10.1002/sim.3682>
Chamorey Emmanuel. (2009). Methodologie des essais de phase precoce en cancerologie: evolution des schemas et apport de la pharmacologie. These.
Garret-Mayer Elizabeth. (2006). The Continual Reassessment Method for dose-finding studies: a tutorial. Clinical Trials: 57-71. <https://doi.org/10.1191/1740774506cn134oa>
See Also
Examples
ssim3p3(c(0.1,0.2,0.25,0.35),100)