Time-to-Event Dose-Finding Design for Multiple Toxicity Grades

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Documentation for package ‘TITEgBOIN’ version 0.3.0

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get_oc_TITE_QuasiBOIN Generate operating characteristics for finding the maxinum tolerated dose (MTD) using Bayesian optimal interval (BOIN), Generalized Bayesian optimal interval (gBOIN), Time-to-event bayesian optimal interval (TITEBOIN) and Time-to-event generalized bayesian optimal interval (TITEgBOIN) designs
next_TITE_QuasiBOIN Determine the dose for the next cohort of new patients for single-agent trials using Bayesian optimal interval (BOIN) (Yuan et al. 2016)/Generalized Bayesian optimal interval (gBOIN) (Mu et al. 2019)/Time-to-event bayesian optimal interval (TITEBOIN) (Lin et al. 2020)/Time-to-event generalized bayesian optimal interval (TITEgBOIN) (Takeda et al. 2022) designs.
select_mtd_TITE_QuasiBOIN Obtain the maximum tolerated dose (MTD) of Bayesian optimal interval (BOIN)/Generalized Bayesian optimal interval (gBOIN)/Time-to-event bayesian optimal interval (TITEBOIN)/Time-to-event generalized bayesian optimal interval (TITEgBOIN) designs