calculateCutoffs |
Calculate data filtering results and two cutoffs for given sensitivity and specificity threshold |
createData |
Generate simulation data |
discretizeAge |
Discretize the age variable according to the two cut-off points |
findCutoffs |
Finding the two cut-off points |
fitLogisticRegression |
Fit a logistic regression model and return the OR and 95% confidence interval |
fitSemiParamModel |
Fit the data using a semi-parametric model to explore the nonlinear dose-response relationship between the independent variable and lnOR |