Schizo_Bin {Surrogate} | R Documentation |
Data of a clinical trial in Schizophrenia (with binary outcomes).
Description
These are the data of a clinical trial in Schizophrenia (a subset of the dataset Schizo_Bin
, study 1
where the patients were administered 10
mg. of haloperidol or 8
mg. of risperidone). A total of 454
patients were treated by 117
investigators (psychiatrists). Patients' schizophrenia symptoms at baseline and at the end of the study (after 8
weeks) were measured using the PANSS and BPRS.
The variables BPRS_Bin and PANSS_Bin are binary outcomes that indicate whether clinically meaningful change had occurred (1 = a reduction of 20
% or higher in the PANSS/BPRS scores at the last measurement compared to baseline; 0 = no such reduction; Leucht et al., 2005; Kay et al., 1988).
Usage
data(Schizo_Bin)
Format
A data.frame
with 454
observations on 5
variables.
Id
The patient ID.
InvestI
The ID of the investigator (psychiatrist) who treated the patient.
Treat
The treatment indicator, coded as
-1
= control treatment (10 mg. haloperidol) and1
= experimental treatment (8 mg. risperidone).PANSS_Bin
The dichotomized change in the PANSS score (1 = a reduction of
20
% or more in the PANSS score, 0=otherwise)BPRS_Bin
The dichotomized change in the BPRS score (1 = a reduction of
20
% or more in the BPRS score, 0=otherwise)CGI_Bin
The sichtomized change in the CGI score, coded as
1
= a change of more than3
points on the original scale (score at the end of the treatment relative to score at the beginning of the treatment),0
= otherwise.
References
Kay, S.R., Opler, L.A., & Lindenmayer, J.P. (1988). Reliability and validity of the Positive and Negative Syndrome Scale for schizophrenics. Psychiatric Research, 23, 99-110.
Leucht, S., et al. (2005). Clinical implications of Brief Psychiatric Rating Scale scores. The British Journal of Psychiarty, 187, 366-371.