AdjStats {StructFDR}

Prior Structure-Adjusted Statistic

Description

Produce the prior structure-adjusted statistic.

Usage

AdjStats(y, V, k, mu, fudge=0.005)

Arguments

y

a vector or a matrix of unadjusted z-values

V

a correlation matrix defined based on the prior structure

k

a numeric value representing the ratio of variance components

mu

a numeric value of the mean of the prior distribution

fudge

a small numeric value added to the diagonal of the correlation matrix to improve stability

Value

a vector or a matrix of adjusted z-values

Author(s)

Jun Chen

References

Xiao, J., Cao, H., Chen, J. (2017). False discovery rate control incorporating phylogenetic tree increases detection power in microbiome-wide multiple testing. Bioinformatics, 33(18), 2873-2881.