ssc_meancomp {SampleSize4ClinicalTrials} | R Documentation |
Sample Size Calculation for the Comparison of Means in Phase III Clinical Trials
Description
This function aims to calculate sample size for the comparison of means in Phase III clinical trials.
Usage
ssc_meancomp(design, ratio, alpha, power, sd, theta, delta)
Arguments
design |
The design of the clinical trials.
|
ratio |
The ratio between the number of subjects in the treatment arm and that in the control arm |
alpha |
Type I error rate |
power |
Statistical power of the test (1-type II error rate) |
sd |
The standard deviation of observed outcomes in both arms |
theta |
The true mean difference between two arms |
delta |
The prespecified superiority, non-inferiority or equivalence margin |
Value
samplesize
References
Chow S, Shao J, Wang H. 2008. Sample Size Calculations in Clinical Research. 2nd Ed. Chapman & Hall/CRC Biostatistics Series.
Yin, G. 2012. Clinical Trial Design: Bayesian and Frequentist Adaptive Methods. John Wiley & Sons.
Examples
##The comparison of means, a non-inferiority trial and the non-inferiority margin is -0.05
ssc_meancomp(design = 3L, ratio = 1, alpha = 0.05, power = 0.8, sd = 0.1, theta = 0, delta = -0.05)