| rejectprob {STARTdesign} | R Documentation |
Rejection Probability Calculation
Description
Calculate the probability of rejecting the null hypothesis at the end of the second stage in the Single-to-double Arm Transition Design
Usage
rejectprob(pe,ps,n1,n2,r1,z)
Arguments
pe |
The response rate of the experimental arm. |
ps |
The response rate of the standard arm. |
n1 |
The number of subjects in the experiemntal arm in the single-arm stage. |
n2 |
The number of subjects in each arm in the double-arm stage. |
r1 |
The minimum number of responses to achieve in the single-arm stage in order for the trial to proceed into the next stage. |
z |
The threshold value for the Z test, i.e., the Z statistic should be greater than |
Value
n1 |
The number of subjects in the experiemntal arm in the single-arm stage. |
n2 |
The number of subjects in each arm in the double-arm stage. |
r1 |
The minimum number of responses to achieve in the single-arm stage in order for the trial to proceed into the next stage.The number of responses observed at the end of single-arm stage should be greater than or equal to |
ess0 |
The expected sample size under the null hypothesis. |
ess1 |
The expected sample size under the alternative hypothesis. |
asn |
The average sample number taken as the average of |
Author(s)
Haolun Shi <shl2003@connect.hku.hk>,
Guosheng Yin <gyin@hku.hk>
References
Shi H., Yin G. (2017), START: Single-to-double Arm Transition Design for Phase II Clinical Trials.
Examples
rejectprob(pe=0.2,ps=0.4,n1=20,n2=40,r1=10,z=qnorm(0.9))