| findparameter {STARTdesign} | R Documentation |
Parameter Calibration
Description
Calibrate the design parameters for the Single-to-double Arm Transition Design
Usage
findparameter(p0,p1,alpha1,beta1,alpha2,beta2)
Arguments
p0 |
The minimally required level for the response rate to be clinically meaningful. |
p1 |
The desirable target rate. |
alpha1 |
The type I error rate in the first stage. |
beta1 |
The type II error rate in the first stage. |
alpha2 |
The type I error rate in the second stage. |
beta2 |
The type II error rate in the second stage. |
Value
n1 |
The number of subjects in the experimental arm in the single-arm stage. |
n2 |
The number of subjects in each arm in the double-arm stage. |
r1 |
The minimum number of responses to achieve in the single-arm stage in order for the trial to proceed into the next stage.The number of responses observed at the end of single-arm stage should be greater than or equal to |
ess0 |
The expected sample size under the null hypothesis. |
ess1 |
The expected sample size under the alternative hypothesis. |
asn |
The average sample number taken as the average of |
Author(s)
Haolun Shi <shl2003@connect.hku.hk>,
Guosheng Yin <gyin@hku.hk>
References
Shi H., Yin G. (2017), START: Single-to-double Arm Transition Design for Phase II Clinical Trials. Submitted.
Examples
findparameter(p0=0.2,p1=0.5,alpha1=0.25,beta1=0.05,alpha2=0.2,beta2=0.25)