Est.Inpar {SPmlficmcm}

Computes the initial values

Description

Computes initial values of the model parameters.

Usage

Est.Inpar(fl, N, gnma, gnch, tab1, typ, p = NULL)

Arguments

fl

Model formula.

N

Numeric vector containing the number of eligible cases( N1 ) and controls ( N0) in the population N = ( N0, N1 ).

gnma

Name of mother genotype variable.

gnch

Name of offspring genotype variable.

tab1

data.frame of the database.

typ

Argument that specifies whether the data are complete (1) or there are missing offspring genotypes (2).

p

Disease prevalence.

Details

The function use logistic regression to evaluate the initial values of the equation parameters given by the formula and uses empirical estimation to compute the initial values of the nonlinear system. For details, see Nguile-Makao et al., (2015).

Value

A list containing components

parms

Initial values of the model parameters given by the formula and the allelic frequency parameter.

ma.u

Initial values of nonlinear system.

References

Moliere Nguile-Makao, Alexandre Bureau (2015).Semi-Parametric Maximum Likelihood Method for Interaction in Case-Mother Control-Mother Designs: Package SPmlficmcm. Journal of Statistical Software, 68(10), 1-17. doi:10.18637/jss.v068.i10