R: Calculated Sum Activity of Step-Up Deiodinases (SPINA-GD)

estimated.GDTT {SPINA}

R Documentation

Calculated Sum Activity of Step-Up Deiodinases (SPINA-GD)

Description

Calculate total step-up deiodinase activity (SPINA-GD) from equilibrium total hormone concentrations.

Usage

estimated.GDTT(T4, T3)

Arguments

`T4`	Total thyroxine (TT4) concentration in nmol/L.
`T3`	Total triiodothyronine (TT3) concentation in pmol/L

Details

This function is able to do vectorised calculations.

Value

This function returns step-up deiodinase activity as a numeric result representing a single value or a vector, depending on the vector length of the arguments. Results are in nmol/s.

Note

The software functions described in this document are intended for research use only. Hormone levels should have been obtained simultaneously in order to avoid bias by transition effects.

Author(s)

Johannes W. Dietrich

References

Dietrich J. W., Landgrafe G., Fotiadou E. H. 2012 TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis. J Thyroid Res. 2012;2012:351864. doi: 10.1155/2012/351864. PMID: 23365787; PMCID: PMC3544290.

Dietrich J. W., Landgrafe-Mende G., Wiora E., Chatzitomaris A., Klein H. H., Midgley J. E., Hoermann R. 2016 Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research. Front Endocrinol (Lausanne). 2016 Jun 9;7:57. doi: 10.3389/fendo.2016.00057. PMID: 27375554; PMCID: PMC4899439.