select.mtd.pop {PoPdesign}

Maximum tolerated dose (MTD) selection for single-agent trials

Description

Select the maximum tolerated dose (MTD) when the single-agent trial is completed

Usage

select.mtd.pop(target, n.pts, n.tox)

Arguments

target

the target DLT rate

n.pts

a vector containing the number of patients treated at each dose level

n.tox

a vector containing the number of patients who experienced dose-limiting toxicity at each dose level

Value

select.mtd.pop() returns (1) selected MTD ($MTD), (2) isotonic estimate of the DLT probablity at each dose and associated

References

Brunk, H., Barlow, R. E., Bartholomew, D. J. & Bremner, J. M (1972, ISBN-13: 978-0471049708).

Examples

### select the MTD for PoP trial
n <- c(4, 4, 16, 8, 0)
y <- c(0, 0, 5, 5, 0)
selmtd <- select.mtd.pop(target=0.3,n.pts=n, n.tox=y)
summary(selmtd)
plot(selmtd)