ReturnMeanControl {Phase123}

Gives true mean survival times for the control therapy.

Description

Returns the mean survival times for the control given efficacy and toxicity dose probability vector, distribution family and linear relationship, effiacy, toxicity and survival.

Usage

ReturnMeanControl(ProbC, betaC, Family, alpha)

Arguments

ProbC

Probability of efficacy and toxicity for the control therapy.

betaC

Linear term for efficacy, toxicity and beta_0 for the control groupar term for efficacy, toxicity and beta_0 for the control group.

Family

Time to event distribution. Options include: Exponential, Gamma, Weibull, Lognormal.

alpha

Shape parameter or standard deviation of a lognormal distribution.

References

[1] Chapple and Thall (2018).A Hybrid Phase I-II/III Clinical Trial Design Allowing Dose Re-Optimization in Phase III. Biometrics. In Press,

Examples

###Family of Distributions
Family="Gamma"
###Shape parameter
alpha=2
##True beta vector for efficacy, toxicity and intercept of the control treatment
betaC=c(.3,-.25,2.389)
##True efficacy and toxicity probability for control group
ProbC = c(.4,.15)
ReturnMeanControl(ProbC,betaC,Family,alpha)