| aIndex {Peptides} | R Documentation |
Compute the aliphatic index of a protein sequence
Description
This function calculates the Ikai (1980) aliphatic index of a protein. The aindex is defined as the relative volume occupied by aliphatic side chains (Alanine, Valine, Isoleucine, and Leucine). It may be regarded as a positive factor for the increase of thermostability of globular proteins.
Usage
aIndex(seq)
Arguments
seq |
An amino-acids sequence |
Details
Aliphatic amino acids (A, I, L and V) are responsible for the thermal stability of proteins. The aliphatic index was proposed by Ikai (1980) and evaluates the thermostability of proteins based on the percentage of each of the aliphatic amino acids that build up proteins.
Value
The computed aliphatic index for a given amino-acids sequence
References
Ikai (1980). Thermostability and aliphatic index of globular proteins. Journal of Biochemistry, 88(6), 1895-1898.
Examples
# COMPARED TO ExPASy ALIPHATIC INDEX
# http://web.expasy.org/protparam/
# SEQUENCE: SDKEVDEVDAALSDLEITLE
# Aliphatic index: 117.00
aIndex(seq = "SDKEVDEVDAALSDLEITLE")
# [1] 117