TwoComp_Volume_RateConstant {PKconverter}

Convert pharmacokinetic parameters for two compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution (V1), elimination rate constant (k10), and transter rate constants (k12, k21)

Usage

TwoComp_Volume_RateConstant(V1,k10,k12,k21,
              V1.sd=NA,k10.sd=NA,k12.sd=NA,k21.sd=NA,
              covar=c(V1k10=NA,V1k12=NA,V1k21=NA,
              k10k12=NA,k10k21=NA,k12k21=NA),...)

Arguments

V1

The volume of distribution of compartment 1

k10

elimination rate constant

k12

transfer rate constants from compartment 1 to compartment 2

k21

transfer rate constants from compartment 2 to compartment 1

V1.sd

standard error of V1

k10.sd

standard error of k10

k12.sd

standard error of k12

k21.sd

standard error of k21

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_RateConstant(V1=5,k10=0.7,k12=0.5,k21=0.05,
         V1.sd=0.01,k10.sd=0.002,k12.sd=0.001,k21.sd=0.0005)