TwoComp_Volume_Exponent {PKconverter}

Convert pharmacokinetic parameters for two compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution(V1), transfer rate constant (k12), and parameters (alpha and beta) in the model "Aexp(-alpha)+Bexp(-beta)"

Usage

TwoComp_Volume_Exponent(V1,alpha,beta,k21,V1.sd=NA,
 alpha.sd=NA,beta.sd=NA,k21.sd=NA,
 covar=c(V1alpha=NA,V1beta=NA,V1k21=NA,alphabeta=NA,
 alphak21=NA,betak21=NA),...)

Arguments

V1

The volume of distribution of compartment 1

alpha

parameter in one compartment model "Aexp(-alpha)"

beta

parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"

k21

transfer rate constants from compartment 2 to compartment 1

V1.sd

standard error of V1

alpha.sd

standard error of alpha

beta.sd

standard error of beta

k21.sd

standard error of k21

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_Exponent(V1=5,alpha=1.221, beta=0.029, k21=0.05,
V1.sd=0.01,alpha.sd=0.01,beta.sd=0.00005,k21.sd=0.0006)