TwoComp_Volume_Clearance_HalfLife {PKconverter}

Convert pharmacokinetic parameters for two compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution(V1), clearance (Cl1) and half-lives (t_alpha and t_beta)

Usage

TwoComp_Volume_Clearance_HalfLife(V1,Cl1,t_alpha,t_beta,
 V1.sd=NA,Cl1.sd=NA,t_alpha.sd=NA,
 t_beta.sd=NA,covar=c(V1Cl1=NA,V1talpha=NA,V1tbeta=NA,Cl1talpha=NA,
   Cl1tbeta=NA,talphatbeta=NA),...)

Arguments

V1

The volume of distribution of compartment 1

Cl1

Clearance from compartment 1

t_alpha

half life of compartment 1

t_beta

half life of compartment 2

V1.sd

standard error of V1

Cl1.sd

standard error of Cl1

t_alpha.sd

standard error of t_alpha

t_beta.sd

standard error of t_beta

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_Clearance_HalfLife(V1=5,Cl1=3.5,t_alpha=0.568,t_beta=24.2,
V1.sd=0.01,Cl1.sd=0.01,t_alpha.sd=0.002,t_beta.sd=0.5)