TwoComp_Volume_Clearance {PKconverter} | R Documentation |
Convert pharmacokinetic parameters for two compartment model
Description
Calculate pharmacokinetic parameters with volume of distributions (V1 and V2) and clearances (Cl1 and Cl2)
Usage
TwoComp_Volume_Clearance(V1,V2,Cl1,Cl2,
V1.sd=NA,V2.sd=NA,Cl1.sd=NA,Cl2.sd=NA,
covar=c(V1V2=0,V1Cl1=0,V1Cl2=0,
V2Cl1=0,V2Cl2=0,Cl1Cl2=0),...)
Arguments
V1 |
The volume of distribution of compartment 1 |
V2 |
The volume of distribution of compartment 2 |
Cl1 |
Clearance from compartment 1 |
Cl2 |
Clearance from compartment 2 |
V1.sd |
standard error of V1 |
V2.sd |
standard error of V2 |
Cl1.sd |
standard error of Cl1 |
Cl2.sd |
standard error of Cl2 |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
References
http://www.nonmemcourse.com/convert.xls
Examples
TwoComp_Volume_Clearance(V1=5,V2=50,Cl1=3.5,Cl2=2.5,
V1.sd=0.01,V2.sd=0.1,Cl1.sd=0.01,Cl2.sd=0.01)
[Package PKconverter version 1.5 Index]