TwoComp_Coefficient_Exponent {PKconverter}

Convert pharmacokinetic parameters for two compartment model

Description

Calculate pharmacokinetic parameters with parameters (A, B, alpha and beta) in two compartment model "Aexp(-alpha)+Bexp(-beta)"

Usage

TwoComp_Coefficient_Exponent(A,B,alpha,beta,
 A.sd=NA,B.sd=NA,alpha.sd=NA,beta.sd=NA,
 covar=c(AB=NA,Aalpha=NA,Abeta=NA,Balpha=NA,Bbeta=NA,alphabeta=NA),...)

Arguments

A

parameter in one compartment model "Aexp(-alpha)"

B

parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"

alpha

parameter in one compartment model "Aexp(-alpha)"

beta

parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"

A.sd

standard error of A

B.sd

standard error of B

alpha.sd

standard error of alpha

beta.sd

standard error of beta

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Coefficient_Exponent(A=0.196,B=0.0036,alpha=1.221,beta=0.0287,
A.sd=0.002,B.sd=0.00005,alpha.sd=0.09,beta.sd=0.0006)