ThreeComp_Volume_Exponent {PKconverter}

Convert pharmacokinetic parameters for three compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution(V1), transfer rate constant (k12 and k31), and parameters (alpha, beta and gamma) in the model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

Usage

ThreeComp_Volume_Exponent(V1,alpha,beta,gamma,k21,k31,
 V1.sd=NA,alpha.sd=NA,beta.sd=NA,gamma.sd=NA,k21.sd=NA,k31.sd=NA,
 covar=c(V1alpha=NA,V1beta=NA,V1gamma=NA,V1k21=NA,V1k31=NA,
   alphabeta=NA,alphagamma=NA,alphak21=NA,alphak31=NA,
   betagamma=NA,betak21=NA,betak31=NA,gammak21=NA,gammak31=NA,
   k21k31=NA),...)

Arguments

V1

The volume of distribution of compartment 1

alpha

parameter in one compartment model "Aexp(-alpha)"

beta

parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"

gamma

parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

k21

transfer rate constants from compartment 2 to compartment 1

k31

transfer rate constants from compartment 3 to compartment 1

V1.sd

standard error of V1

alpha.sd

standard error of alpha

beta.sd

standard error of beta

gamma.sd

standard error of gamma

k21.sd

standard error of k21

k31.sd

standard error of k31

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_Exponent(V1=10,alpha=0.6, beta=0.013, gamma=0.00074,
   k21=0.02, k31=0.001, V1.sd=0.01,alpha.sd=0.01,beta.sd=0.00005,
   gamma.sd=0.000002, k21.sd=0.0006,k31.sd=0.0000005)