ThreeComp_Volume_Clearance_HalfLife {PKconverter}

Convert pharmacokinetic parameters for three compartment model

Description

Calculate pharmacokinetic parameters with volume of distributions (Vd and V1), clearance (Cl1) and half-lives (t_alpha, t_beta, and t_gamma)

Usage

ThreeComp_Volume_Clearance_HalfLife(V1,Vd,Cl1,t_alpha,t_beta,t_gamma,
 V1.sd=NA,Vd.sd=NA,Cl1.sd=NA,t_alpha.sd=NA,t_beta.sd=NA,t_gamma.sd=NA,
 covar=c(V1Vd=NA,V1Cl1=NA,V1talpha=NA,V1tbeta=NA,V1tgamma=NA,VdCl1=NA,
   Vdtalpha=NA,Vdtbeta=NA,Vdtgamma=NA,Cl1talpha=NA,Cl1tbeta=NA,
   Cl1tgamma=NA,talphatbeta=NA,talphatgamma=NA,tbetatgamma=NA),...)

Arguments

V1

The volume of distribution of compartment 1

Vd

Total volume of distributions

Cl1

Clearance from compartment 1

t_alpha

half life of compartment 1

t_beta

half life of compartment 2

t_gamma

half life of compartment 3

V1.sd

standard error of V1

Vd.sd

standard error of Vd

Cl1.sd

standard error of Cl1

t_alpha.sd

standard error of t_alpha

t_beta.sd

standard error of t_beta

t_gamma.sd

standard error of t_gamma

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_Clearance_HalfLife(V1=5,Vd=1110,Cl1=3,
t_alpha=1.142,t_beta=52.2,t_gamma=931, V1.sd=0.01,Vd.sd=20,Cl1.sd=0.01,
t_alpha.sd=0.002,t_beta.sd=0.5,t_gamma.sd=5.6)