ThreeComp_Volume_Clearance {PKconverter}

Convert pharmacokinetic parameters for three compartment model

Description

Calculate pharmacokinetic parameters with volume of distributions (V1, V2 and V3) and clearances (Cl1, Cl2, and Cl3)

Usage

ThreeComp_Volume_Clearance(V1,V2,V3,Cl1,Cl2,Cl3,
 V1.sd=NA,V2.sd=NA,V3.sd=NA, Cl1.sd=NA,Cl2.sd=NA,Cl3.sd=NA,
 covar=c(V1V2=NA,V1V3=NA,V1Cl1=NA,
   V1Cl2=NA,V1Cl3=NA,V2V3=NA,V2Cl1=NA,V2Cl2=NA,V2Cl3=NA,
   V3Cl1=NA,V3Cl2=NA,V3Cl3=NA,Cl1Cl2=NA,Cl1Cl3=NA,Cl2Cl3=NA),...)

Arguments

V1

The volume of distribution of compartment 1

V2

The volume of distribution of compartment 2

V3

The volume of distribution of compartment 3

Cl1

Clearance from compartment 1

Cl2

Clearance from compartment 2

Cl3

Clearance from compartment 3

V1.sd

standard error of V1

V2.sd

standard error of V2

V3.sd

standard error of V3

Cl1.sd

standard error of Cl1

Cl2.sd

standard error of Cl2

Cl3.sd

standard error of Cl3

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_Clearance(V1=10,V2=100,V3=1000,Cl1=3,Cl2=2,Cl3=1,
  V1.sd=0.01,V2.sd=0.1,V3.sd=1,Cl1.sd=0.01,Cl2.sd=0.01,Cl3.sd=0.01)