pk.nca.interval {PKNCA}

Compute all PK parameters for a single concentration-time data set

Description

For one subject/time range, compute all available PK parameters. All the internal options should be set by PKNCA.options() prior to running. The only part that changes with a call to this function is the concentration and time.

Usage

pk.nca.interval(
  conc,
  time,
  volume,
  duration.conc,
  dose,
  time.dose,
  duration.dose,
  route,
  conc.group = NULL,
  time.group = NULL,
  volume.group = NULL,
  duration.conc.group = NULL,
  dose.group = NULL,
  time.dose.group = NULL,
  duration.dose.group = NULL,
  route.group = NULL,
  impute_method = NA_character_,
  include_half.life = NULL,
  exclude_half.life = NULL,
  subject,
  sparse,
  interval,
  options = list()
)

Arguments

conc

Measured concentrations

time

Time of the measurement of the concentrations

volume, volume.group

The volume (or mass) of the concentration measurement for the current interval or all data for the group (typically for urine and fecal measurements)

duration.conc, duration.conc.group

The duration of the concentration measurement for the current interval or all data for the group (typically for urine and fecal measurements)

dose, dose.group

Dose amount (may be a scalar or vector) for the current interval or all data for the group

time.dose, time.dose.group

Time of the dose for the current interval or all data for the group (must be the same length as dose or dose.group)

duration.dose, duration.dose.group

The duration of the dose administration for the current interval or all data for the group (typically zero for extravascular and intravascular bolus and nonzero for intravascular infusion)

route, route.group

The route of dosing for the current interval or all data for the group

conc.group

All concentrations measured for the group

time.group

Time of all concentrations measured for the group

impute_method

The method to use for imputation as a character string

include_half.life

An optional boolean vector of the concentration measurements to include in the half-life calculation. If given, no half-life point selection will occur.

exclude_half.life

An optional boolean vector of the concentration measurements to exclude from the half-life calculation.

subject

Subject identifiers (used for sparse calculations)

sparse

Should only sparse calculations be performed (TRUE) or only dense calculations (FALSE)?

interval

One row of an interval definition (see check.interval.specification() for how to define the interval.

options

List of changes to the default PKNCA options (see PKNCA.options())

Value

A data frame with the start and end time along with all PK parameters for the interval

See Also

check.interval.specification()