pk.calc.vd {PKNCA}

Calculate the volume of distribution (Vd) or observed volume of distribution (Vd/F)

Description

Calculate the volume of distribution (Vd) or observed volume of distribution (Vd/F)

Usage

pk.calc.vd(dose, aucinf, lambda.z)

Arguments

dose

One or more doses given during an interval

aucinf

Area under the curve to infinity (either predicted or observed).

lambda.z

Elimination rate constant

Details

vd is dose/(aucinf * lambda.z).

If dose is the same length as the other inputs, then the output will be the same length as all of the inputs; the function assumes that you are calculating for multiple intervals simultaneously. If the inputs other than dose are scalars and dose is a vector, then the function assumes multiple doses were given in a single interval, and the sum of the doses will be used for the calculation.

Value

The observed volume of distribution