| pk.calc.cl {PKNCA} | R Documentation |
Calculate the (observed oral) clearance
Description
Calculate the (observed oral) clearance
Usage
pk.calc.cl(dose, auc)
Arguments
dose |
the dose administered |
auc |
The area under the concentration-time curve. |
Details
cl is dose/auc.
If dose is the same length as the other inputs, then the output
will be the same length as all of the inputs; the function assumes that you
are calculating for multiple intervals simultaneously. If the inputs other
than dose are scalars and dose is a vector, then the function assumes
multiple doses were given in a single interval, and the sum of the doses
will be used for the calculation.
Value
the numeric value of the total (CL) or observed oral clearance (CL/F)
References
Gabrielsson J, Weiner D. "Section 2.5.1 Derivation of clearance." Pharmacokinetic & Pharmacodynamic Data Analysis: Concepts and Applications, 4th Edition. Stockholm, Sweden: Swedish Pharmaceutical Press, 2000. 86-7.