pk.calc.auciv {PKNCA} | R Documentation |
Calculate AUC for intravenous dosing
Description
Calculate AUC for intravenous dosing
Usage
pk.calc.auciv(conc, time, c0, auc, ..., check = TRUE)
pk.calc.auciv_pbext(auc, auciv)
Arguments
conc |
Measured concentrations |
time |
Time of the measurement of the concentrations |
c0 |
The concentration at time 0, typically calculated using
|
auc |
The AUC calculated using |
... |
For functions other than |
check |
Run |
auciv |
The AUC calculated using |
Details
The AUC for intravenous (IV) dosing extrapolates the AUC back from the first measurement to time 0 using c0 and the AUC calculated by another method (for example the auclast).
The calculation method takes the following steps:
time = 0
must be present in the data with a measured concentration.The AUC between
time = 0
and the next time point is calculated (auc_first
).The AUC between
time = 0
withc0
and the next time point is calculated (auc_second
).The final AUC is the initial AUC plus the difference between the two AUCs (
auc_final <- auc + auc_second - auc_first
).
The calculation for back-extrapolation is 100*(1 - auc/auciv)
.
Value
pk.calc.auciv
: The AUC calculated using c0
pk.calc.auciv_pctbackextrap
: The AUC percent back-extrapolated
Functions
-
pk.calc.auciv_pbext()
: Calculate the percent back-extrapolated AUC for IV administration