pk.calc.aucint {PKNCA}

Calculate the AUC over an interval with interpolation and/or extrapolation of concentrations for the beginning and end of the interval.

Description

Calculate the AUC over an interval with interpolation and/or extrapolation of concentrations for the beginning and end of the interval.

Usage

pk.calc.aucint(
  conc,
  time,
  interval = NULL,
  start = NULL,
  end = NULL,
  clast = pk.calc.clast.obs(conc, time),
  lambda.z = NA,
  time.dose = NULL,
  route = "extravascular",
  duration.dose = 0,
  method = NULL,
  auc.type = "AUClast",
  conc.blq = NULL,
  conc.na = NULL,
  check = TRUE,
  ...,
  options = list()
)

pk.calc.aucint.last(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  ...,
  options = list()
)

pk.calc.aucint.all(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  ...,
  options = list()
)

pk.calc.aucint.inf.obs(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  lambda.z,
  clast.obs,
  ...,
  options = list()
)

pk.calc.aucint.inf.pred(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  lambda.z,
  clast.pred,
  ...,
  options = list()
)

Arguments

conc

Measured concentrations

time

Time of the measurement of the concentrations

interval

Numeric vector of two numbers for the start and end time of integration

start

The start time of the interval

end

The end time of the interval

clast, clast.obs, clast.pred

The last concentration above the limit of quantification; this is used for AUCinf calculations. If provided as clast.obs (observed clast value, default), AUCinf is AUCinf,obs. If provided as clast.pred, AUCinf is AUCinf,pred.

lambda.z

The elimination rate (in units of inverse time) for extrapolation

time.dose, route, duration.dose

The time of doses, route of administration, and duration of dose used with interpolation and extrapolation of concentration data (see interp.extrap.conc.dose()). If NULL, interp.extrap.conc() will be used instead (assuming that no doses affecting concentrations are in the interval).

method

The method for integration (one of 'lin up/log down', 'lin-log', or 'linear')

auc.type

The type of AUC to compute. Choices are 'AUCinf', 'AUClast', and 'AUCall'.

conc.blq

How to handle BLQ values in between the first and last above LOQ concentrations. (See clean.conc.blq() for usage instructions.)

conc.na

How to handle missing concentration values. (See clean.conc.na() for usage instructions.)

check

Run assert_conc_time(), clean.conc.blq(), and clean.conc.na()?

...

Additional arguments passed to pk.calc.auxc and interp.extrap.conc

options

List of changes to the default PKNCA options (see PKNCA.options())

Details

When pk.calc.aucint() needs to extrapolate using lambda.z (in other words, using the half-life), it will always extrapolate using the logarithmic trapezoidal rule to align with using a half-life calculation for the extrapolation.

Value

The AUC for an interval of time as a number

Functions

• pk.calc.aucint.last(): Interpolate or extrapolate concentrations for AUClast

• pk.calc.aucint.all(): Interpolate or extrapolate concentrations for AUCall

• pk.calc.aucint.inf.obs(): Interpolate or extrapolate concentrations for AUCinf.obs

• pk.calc.aucint.inf.pred(): Interpolate or extrapolate concentrations for AUCinf.pred

See Also

PKNCA.options(), interp.extrap.conc.dose()

Other AUC calculations: pk.calc.auxc()