exclude_nca {PKNCA}

Exclude NCA parameters based on examining the parameter set.

Description

Exclude NCA parameters based on examining the parameter set.

Usage

exclude_nca_span.ratio(min.span.ratio)

exclude_nca_max.aucinf.pext(max.aucinf.pext)

exclude_nca_min.hl.r.squared(min.hl.r.squared)

Arguments

min.span.ratio

The minimum acceptable span ratio (uses PKNCA.options("min.span.ratio") if not provided).

max.aucinf.pext

The maximum acceptable percent AUC extrapolation (uses PKNCA.options("max.aucinf.pext") if not provided).

min.hl.r.squared

The minimum acceptable r-squared value for half-life (uses PKNCA.options("min.hl.r.squared") if not provided).

Functions

• exclude_nca_span.ratio(): Exclude based on span.ratio

• exclude_nca_max.aucinf.pext(): Exclude based on AUC percent extrapolated (both observed and predicted)

• exclude_nca_min.hl.r.squared(): Exclude based on half-life r-squared

See Also

Other Result exclusions: exclude()

Examples

my_conc <- PKNCAconc(data.frame(conc=1.1^(3:0),
                                time=0:3,
                                subject=1),
                     conc~time|subject)
my_data <- PKNCAdata(my_conc,
                     intervals=data.frame(start=0, end=Inf,
                                          aucinf.obs=TRUE,
                                          aucpext.obs=TRUE))
my_result <- pk.nca(my_data)
my_result_excluded <- exclude(my_result,
                              FUN=exclude_nca_max.aucinf.pext())
as.data.frame(my_result_excluded)