auc_integrate {PKNCA}

Support function for AUC integration

Description

Support function for AUC integration

Usage

auc_integrate(
  conc,
  time,
  clast,
  tlast,
  lambda.z,
  interval_method,
  fun_linear,
  fun_log,
  fun_inf
)

Arguments

conc

Measured concentrations

time

Time of the measurement of the concentrations

clast

The last concentration above the limit of quantification

tlast

Time of last concentration above the limit of quantification (will be calculated, if not provided)

lambda.z

The elimination rate (in units of inverse time) for extrapolation

interval_method

The method for integrating each interval of conc

fun_linear

The function to use for integration of the linear part of the curve (not required for AUC or AUMC functions)

fun_log

The function to use for integration of the logarithmic part of the curve (if log integration is used; not required for AUC or AUMC functions)

fun_inf

The function to use for extrapolation from the final measurement to infinite time (not required for AUC or AUMC functions.