| Rats {PK} | R Documentation |
Plasma levels in female rats following a single oral dose
Description
The Rats data frame has 126 rows and 4 columns.
Format
This data frame contains the following columns:
- id
-
a numeric vector identifying the animal whose plasma level is measured.
- conc
-
a numeric vector giving the measured plasma level (microgram/mL).
- time
-
a numeric vector giving the time since administration (hours).
- dose
-
a numeric vector indicating the dose administred (mg/kg).
Details
Holder et al. (1999), Table 4 describes data on the plasma levels measured at 6 time points over 24 hours for 9
female rats. The same experiment was repeated with different oral dosages.
Source
Holder D. J., Hsuan F., Dixit R. and Soper K. (1999). A method for estimating and testing area under the curve in serial sacrifice, batch, and complete data designs. Journal of Biopharmaceutical Statistics, 9(3):451-464.