Population Fisher Information Matrix

---

Documentation for package ‘PFIM’ version 6.0.3

• DESCRIPTION file.
• User guides, package vignettes and other documentation.

Help Pages

A B C D E F G I L M N O P R S misc

PFIM-package

Fisher Information matrix for design evaluation/optimization for nonlinear mixed effects models.

-- A --

addModel	Add a model to a library of models.
addModel-method	Add a model to a library of models.
addModels	Add a models to a library of models.
addModels-method	Add a models to a library of models.
Administration	Class "Administration"
Administration-class	Class "Administration"
AdministrationConstraints	Class "AdministrationConstraints"
AdministrationConstraints-class	Class "AdministrationConstraints"
Arm	Class "Arm"
Arm-class	Class "Arm"

-- B --

BayesianFim	Class "BayesianFim"
BayesianFim-class	Class "BayesianFim"

-- C --

checkSamplingTimeConstraintsForContinuousOptimization	Check for the samplingTime constraints for continuous optimization
checkSamplingTimeConstraintsForContinuousOptimization-method	Check for the samplingTime constraints for continuous optimization
checkValiditySamplingConstraint	checkValiditySamplingConstraint
checkValiditySamplingConstraint-method	checkValiditySamplingConstraint
Combined1	Class "Combined1"
Combined1-class	Class "Combined1"
Constant	Class "Constant"
Constant-class	Class "Constant"
convertPKModelAnalyticToPKModelODE	Convert an analytic model to a ode model.
convertPKModelAnalyticToPKModelODE-method	Convert an analytic model to a ode model.

-- D --

defineModel	Define a model.
defineModel-method	Define a model.
defineModelFromLibraryOfModels	Define a model from the library of models.
defineModelFromLibraryOfModels-method	Define a model from the library of models.
defineModelType	Define the type of a model.
defineModelType-method	Define the type of a model.
defineModelUserDefined	Define a user defined model.
defineModelUserDefined-method	Define a user defined model.
definePKModel	Define a PK model.
definePKModel-method	Define a PK model.
definePKPDModel	Define a PKPD model.
definePKPDModel-method	Define a PKPD model.
Design	Class "Design"
Design-class	Class "Design"
Distribution	Class "Distribution"
Distribution-class	Class "Distribution"

-- E --

EvaluateArm	EvaluateArm
EvaluateArm-method	EvaluateArm
EvaluateDesign	EvaluateDesign
EvaluateDesign-method	EvaluateDesign
EvaluateErrorModelDerivatives	Evaluate the error model derivatives.
EvaluateErrorModelDerivatives-method	Evaluate the error model derivatives.
EvaluateFisherMatrix	Evaluate the Fisher matrix ( population, individual and Bayesian )
EvaluateFisherMatrix-method	Evaluate the Fisher matrix ( population, individual and Bayesian )
EvaluateModel	Evaluate a model.
EvaluateModel-method	Evaluate a model.
EvaluateVarianceFIM	Evaluate the variance of the Fisher information matrix.
EvaluateVarianceFIM-method	Evaluate the variance of the Fisher information matrix.
EvaluateVarianceModel	Evaluate the variance of a model.
EvaluateVarianceModel-method	Evaluate the variance of a model.
Evaluation	Class "Evaluation"
Evaluation-class	Class "Evaluation"

-- F --

FedorovWynnAlgorithm	Class "FedorovWynnAlgorithm"
FedorovWynnAlgorithm-class	Class "FedorovWynnAlgorithm"
FedorovWynnAlgorithm_Rcpp	Fedorov-Wynn algorithm in Rcpp.
Fim	Class "Fim"
Fim-class	Class "Fim"
fisher.simplex	Compute the fisher.simplex
fun.amoeba	function fun.amoeba

-- G --

generateFimsFromConstraints	Generate the fim from the constraints
generateFimsFromConstraints-method	Generate the fim from the constraints
generateReportEvaluation	Generate the report for the evaluation
generateReportEvaluation-method	Generate the report for the evaluation
generateReportOptimization	Generate report for the optimization.
generateReportOptimization-method	Generate report for the optimization.
generateSamplingsFromSamplingConstraints	Generate samplings from sampling constraints
generateSamplingsFromSamplingConstraints-method	Generate samplings from sampling constraints
generateTables	Generate the tables for the report.
generateTables-method	Generate the tables for the report.
getAdjustedGradient	getAdjustedGradient
getAdjustedGradient-method	getAdjustedGradient
getAdministration	getAdministration
getAdministration-method	getAdministration
getAdministrationConstraint	getAdministrationConstraint
getAdministrationConstraint-method	getAdministrationConstraint
getAdministrations	getAdministrations
getAdministrations-method	getAdministrations
getAdministrationsConstraints	getAdministrationsConstraints
getAdministrationsConstraints-method	getAdministrationsConstraints
getArms	Get the arms of an object.
getArms-method	Get the arms of an object.
getcError	Get the parameter c.
getcError-method	Get the parameter c.
getColumnAndParametersNamesFIM	Get the names of the names of the parameters associated to each column of the fim.
getColumnAndParametersNamesFIM-method	Get the names of the names of the parameters associated to each column of the fim.
getColumnAndParametersNamesFIMInLatex	Get the names of the names of the parameters associated to each column of the fim in Latex format.
getColumnAndParametersNamesFIMInLatex-method	Get the names of the names of the parameters associated to each column of the fim in Latex format.
getConditionNumberFixedEffects	Get the condition number of the matrix of the fixed effects.
getConditionNumberFixedEffects-method	Get the condition number of the matrix of the fixed effects.
getConditionNumberVarianceEffects	Get the condition number of the matrix of the variance effects.
getConditionNumberVarianceEffects-method	Get the condition number of the matrix of the variance effects.
getContent	Get content of a library of models.
getContent-method	Get content of a library of models.
getCorrelationMatrix	Get the correlation matrix.
getCorrelationMatrix-method	Get the correlation matrix.
getDataFrameResults	Get the dataframe of the results.
getDataFrameResults-method	Get the dataframe of the results.
getDcriterion	Get the D criterion of the fim.
getDcriterion-method	Get the D criterion of the fim.
getDelta	Get the parameter delta
getDelta-method	Get the parameter delta
getDerivatives	Get the derivatives of the model error equation.
getDerivatives-method	Get the derivatives of the model error equation.
getDescription	Get the description of a model.
getDescription-method	Get the description of a model.
getDesigns	Get the designs.
getDesigns-method	Get the designs.
getDeterminant	Get the determinant of the fim.
getDeterminant-method	Get the determinant of the fim.
getDistribution	Get the distribution.
getDistribution-method	Get the distribution.
getDose	getDose
getDose-method	getDose
getEigenValues	Get the eigenvalues of the fim.
getEigenValues-method	Get the eigenvalues of the fim.
getElementaryProtocols	Get the elementary protocols.
getElementaryProtocols-method	Get the elementary protocols.
getEquation	Get the equation of a model error.
getEquation-method	Get the equation of a model error.
getEquations	Get the equations of a model.
getEquations-method	Get the equations of a model.
getEquationsAfterInfusion	Get the equations after infusion.
getEquationsAfterInfusion-method	Get the equations after infusion.
getEquationsDuringInfusion	Get the equations during infusion.
getEquationsDuringInfusion-method	Get the equations during infusion.
getEvaluationFIMResults	Get the results of the evaluation.
getEvaluationFIMResults-method	Get the results of the evaluation.
getEvaluationInitialDesignResults	Get the evaluation results of the initial design.
getEvaluationInitialDesignResults-method	Get the evaluation results of the initial design.
getFim	getFim
getFim-method	getFim
getFisherMatrix	Get the FIM.
getFisherMatrix-method	Get the FIM.
getFixedEffects	Get the matrix of fixed effects.
getFixedEffects-method	Get the matrix of fixed effects.
getFixedMu	Get the fixed effect.
getFixedMu-method	Get the fixed effect.
getFixedOmega	Get the fixed variance.
getFixedOmega-method	Get the fixed variance.
getFixedParameters	Get the fixed parameters.
getFixedParameters-method	Get the fixed parameters.
getFixedTimes	Get the fixed sampling times.
getFixedTimes-method	Get the fixed sampling times.
getInitialConditions	getInitialConditions
getInitialConditions-method	getInitialConditions
getIterationAndCriteria	Get the iteration with the convergence criteria.
getIterationAndCriteria-method	Get the iteration with the convergence criteria.
getLambda	Get the parameter lambda.
getLambda-method	Get the parameter lambda.
getLibraryPDModels	Get the library of PD models.
getLibraryPDModels-method	Get the library of PD models.
getLibraryPKModels	Get the library of PK models.
getLibraryPKModels-method	Get the library of PK models.
getMinSampling	Get the minimal sampling times.
getMinSampling-method	Get the minimal sampling times.
getModel	Get the model.
getModel-method	Get the model.
getModelEquations	Get the model equations.
getModelEquations-method	Get the model equations.
getModelError	Get the model error.
getModelError-method	Get the model error.
getModelErrorParametersValues	Get the values of the model error parameters.
getModelErrorParametersValues-method	Get the values of the model error parameters.
getModelFromLibrary	Get a model from the library of models.
getModelFromLibrary-method	Get a model from the library of models.
getModelParameters	Get the model parameters.
getModelParameters-method	Get the model parameters.
getModelParametersValues	Get the values of the model parameters.
getModelParametersValues-method	Get the values of the model parameters.
getMu	getMu
getMu-method	getMu
getName	getName
getName-method	getName
getNames	getNames
getNames-method	getNames
getNumberOfArms	getNumberOfArms
getNumberOfArms-method	getNumberOfArms
getNumberOfIterations	Get the number of iterations.
getNumberOfIterations-method	Get the number of iterations.
getNumberOfParameters	Get the number of parameters.
getNumberOfParameters-method	Get the number of parameters.
getNumberOfsamplingsOptimisable	Get the number of sampling times that are optimisable.
getNumberOfsamplingsOptimisable-method	Get the number of sampling times that are optimisable.
getNumberOfTimesByWindows	Get the number of sampling times by windows.
getNumberOfTimesByWindows-method	Get the number of sampling times by windows.
getOdeSolverParameters	getOdeSolverParameters
getOdeSolverParameters-method	getOdeSolverParameters
getOmega	Get the matrix omega of an object.
getOmega-method	Get the matrix omega of an object.
getOptimalDesign	Get the optimal design.
getOptimalDesign-method	Get the optimal design.
getOptimalFrequencies	Get the optimal frequencies
getOptimalFrequencies-method	Get the optimal frequencies
getOptimalWeights	Get the optimal weights.
getOptimalWeights-method	Get the optimal weights.
getOptimizationResults	Get the optimization results.
getOptimizationResults-method	Get the optimization results.
getOptimizer	Get the optimization algorithm.
getOptimizer-method	Get the optimization algorithm.
getOptimizerParameters	Get the optimization parameters.
getOptimizerParameters-method	Get the optimization parameters.
getOutcome	getOutcome
getOutcome-method	getOutcome
getOutcomes	Get the outcomes of a model.
getOutcomes-method	Get the outcomes of a model.
getOutcomesEvaluation	getOutcomesEvaluation
getOutcomesEvaluation-method	getOutcomesEvaluation
getOutcomesForEvaluation	Get the outcomes of a model used for the evaluation (is scales outcomes).
getOutcomesForEvaluation-method	Get the outcomes of a model used for the evaluation (is scales outcomes).
getOutcomesGradient	getOutcomesGradient
getOutcomesGradient-method	getOutcomesGradient
getParameters	Get the parameters of an object.
getParameters-method	Get the parameters of an object.
getPDModel	Get a PD model.
getPDModel-method	Get a PD model.
getPKModel	Get a PK model.
getPKModel-method	Get a PK model.
getPKPDModel	Get a PKPD model.
getPKPDModel-method	Get a PKPD model.
getPlotOptions	Get the plot options for graphs responses and SI
getProportionsOfSubjects	Get the proportion of subjects.
getProportionsOfSubjects-method	Get the proportion of subjects.
getRSE	Get the RSE
getRSE-method	Get the RSE
getSamplings	Get the sampling of an object.
getSamplings-method	Get the sampling of an object.
getSamplingsWindows	Get the windows for the sampling times.
getSamplingsWindows-method	Get the windows for the sampling times.
getSamplingTime	getSamplingTime
getSamplingTime-method	getSamplingTime
getSamplingTimeConstraint	getSamplingTimeConstraint
getSamplingTimeConstraint-method	getSamplingTimeConstraint
getSamplingTimes	getSamplingTimes
getSamplingTimes-method	getSamplingTimes
getSamplingTimesConstraints	getSamplingTimesConstraints
getSamplingTimesConstraints-method	getSamplingTimesConstraints
getSE	Get the SE.
getSE-method	Get the SE.
getShrinkage	Get the shrinkage.
getShrinkage-method	Get the shrinkage.
getSigmaInter	Get the parameter sigma inter.
getSigmaInter-method	Get the parameter sigma inter.
getSigmaSlope	Get the parameter sigma slope.
getSigmaSlope-method	Get the parameter sigma slope.
getSize	getSize
getSize-method	getSize
getTau	getTau
getTau-method	getTau
getTimeDose	getTimeDose
getTimeDose-method	getTimeDose
getTinf	Get the infusion duration.
getTinf-method	Get the infusion duration.
getVarianceEffects	Get the matrix of the variance effects.
getVarianceEffects-method	Get the matrix of the variance effects.

-- I --

IndividualFim	Class "Fim"
IndividualFim-class	Class "Fim"
isDoseInEquations	Test if the dose is in the equations of the model.
isDoseInEquations-method	Test if the dose is in the equations of the model.
isModelAnalytic	Test if a mode is analytic.
isModelAnalytic-method	Test if a mode is analytic.
isModelBolus	Test if a mode is bolus.
isModelBolus-method	Test if a mode is bolus.
isModelInfusion	Test if a mode is infusion
isModelInfusion-method	Test if a mode is infusion
isModelODE	Test if a mode is ode.
isModelODE-method	Test if a mode is ode.
isModelSteadyState	Test if a mode is steady state.
isModelSteadyState-method	Test if a mode is steady state.

-- L --

LibraryOfModels	Class "LibraryOfModels"
LibraryOfModels-class	Class "LibraryOfModels"
LibraryOfPDModels	Library of the PK models
LibraryOfPKModels	Library of the PK models
LibraryOfPKPDModels	Class "LibraryOfPKPDModels"
LibraryOfPKPDModels-class	Class "LibraryOfPKPDModels"
LogNormal	Class "LogNormal"
LogNormal-class	Class "LogNormal"

-- M --

Model	Class "Model"
Model-class	Class "Model"
ModelAnalytic	Class "ModelAnalytic"
ModelAnalytic-class	Class "ModelAnalytic"
ModelAnalyticBolus	Class "ModelAnalyticBolus"
ModelAnalyticBolus-class	Class "ModelAnalyticBolus"
ModelAnalyticBolusSteadyState	Class "ModelAnalyticBolusSteadyState"
ModelAnalyticBolusSteadyState-class	Class "ModelAnalyticBolusSteadyState"
ModelAnalyticInfusion	Class "ModelAnalyticInfusion"
ModelAnalyticInfusion-class	Class "ModelAnalyticInfusion"
ModelAnalyticInfusionSteadyState	Class "ModelAnalyticInfusionSteadyState"
ModelAnalyticInfusionSteadyState-class	Class "ModelAnalyticInfusionSteadyState"
ModelAnalyticSteadyState	Class "ModelAnalyticSteadyState"
ModelAnalyticSteadyState-class	Class "ModelAnalyticSteadyState"
ModelBolus	Class "ModelBolus"
ModelBolus-class	Class "ModelBolus"
ModelError	Class "ModelError" representing a Model error.
ModelError-class	Class "ModelError" representing a Model error.
ModelInfusion	Class "ModelInfusion"
ModelInfusion-class	Class "ModelInfusion"
ModelODE	Class "ModelODE"
ModelODE-class	Class "ModelODE"
ModelODEBolus	Class "ModelODEBolus"
ModelODEBolus-class	Class "ModelODEBolus"
ModelODEDoseInEquations	Class "ModelODEDoseInEquations"
ModelODEDoseInEquations-class	Class "ModelODEDoseInEquations"
ModelODEDoseNotInEquations	Class "ModelODEDoseNotInEquations"
ModelODEDoseNotInEquations-class	Class "ModelODEDoseNotInEquations"
ModelODEInfusion	Class "ModelODEInfusion"
ModelODEInfusion-class	Class "ModelODEInfusion"
ModelODEInfusionDoseInEquations	Class "ModelODEInfusionDoseInEquations"
ModelODEInfusionDoseInEquations-class	Class "ModelODEInfusionDoseInEquations"
ModelParameter	Class "ModelParameter"
ModelParameter-class	Class "ModelParameter"
MultiplicativeAlgorithm	Class "MultiplicativeAlgorithm"
MultiplicativeAlgorithm-class	Class "MultiplicativeAlgorithm"
MultiplicativeAlgorithm_Rcpp	Function MultiplicativeAlgorithm_Rcpp

-- N --

Normal	Class "Normal"
Normal-class	Class "Normal"

-- O --

Optimization	Class "Optimization"
Optimization-class	Class "Optimization"
OptimizationAlgorithm	Class "OptimizationAlgorithm"
OptimizationAlgorithm-class	Class "OptimizationAlgorithm"
optimize	Optimize a design.
optimize-method	Optimize a design.

-- P --

package-PFIM	Fisher Information matrix for design evaluation/optimization for nonlinear mixed effects models.
parametersForComputingGradient	Define the parameters for computing the gradients of a model.
parametersForComputingGradient-method	Define the parameters for computing the gradients of a model.
PFIM,	Fisher Information matrix for design evaluation/optimization for nonlinear mixed effects models.
PFIMProject	Class "PFIMProject"
PFIMProject-class	Class "PFIMProject"
PGBOAlgorithm	Class "PGBOAlgorithm"
PGBOAlgorithm-class	Class "PGBOAlgorithm"
PlotEvaluation	Class "PlotEvaluation"
plotEvaluation	Graphs of the results of the evaluation.
PlotEvaluation-class	Class "PlotEvaluation"
plotEvaluation-method	Graphs of the results of the evaluation.
plotFrequencies	Graph of the frequencies for the FW algorithm.
plotFrequencies-method	Graph of the frequencies for the FW algorithm.
plotOutcomesEvaluation	plotOutcomesEvaluation
plotOutcomesEvaluation-method	plotOutcomesEvaluation
plotOutcomesGradient	plotOutcomesGradient
plotOutcomesGradient-method	plotOutcomesGradient
plotRSE	Graph of the RSE.
plotRSE-method	Graph of the RSE.
plotSE	Graph the SE.
plotSE-method	Graph the SE.
plotSensitivityIndice	Graphs of the results of the evaluation.
plotSensitivityIndice-method	Graphs of the results of the evaluation.
plotShrinkage	Graph of the shrinkage.
plotShrinkage-method	Graph of the shrinkage.
plotWeights	Graph of the weights for the multiplicative algorithm.
plotWeights-method	Graph of the weights for the multiplicative algorithm.
PopulationFim	Class "PopulationFim"
PopulationFim-class	Class "PopulationFim"
Proportional	Class "Proportional"
Proportional-class	Class "Proportional"
PSOAlgorithm	Class "PSOAlgorithm"
PSOAlgorithm-class	Class "PSOAlgorithm"

-- R --

Report	Report
Report-method	Report
reportTablesAdministration	reportTablesAdministration
reportTablesAdministration-method	reportTablesAdministration
reportTablesDesign	reportTablesDesign
reportTablesDesign-method	reportTablesDesign
reportTablesFIM	Generate the tables for the report.
reportTablesFIM-method	Generate the tables for the report.
reportTablesModelError	Generate the tables for model errors for the evaluation report.
reportTablesModelError-method	Generate the tables for model errors for the evaluation report.
reportTablesModelParameters	Generate the tables for model parameters for the evaluation report.
reportTablesModelParameters-method	Generate the tables for model parameters for the evaluation report.
reportTablesPlot	reportTablesPlot
reportTablesPlot-method	reportTablesPlot
reportTablesSamplingConstraints	reportTablesSamplingConstraints
reportTablesSamplingConstraints-method	reportTablesSamplingConstraints
resizeFisherMatrix	Resize the fisher Matrix from a vector to a matrix.
resizeFisherMatrix-method	Resize the fisher Matrix from a vector to a matrix.
run	run
run-method	run

-- S --

SamplingTimeConstraints	Class "SamplingTimeConstraints"
SamplingTimeConstraints-class	Class "SamplingTimeConstraints"
SamplingTimes	Class "SamplingTimes"
SamplingTimes-class	Class "SamplingTimes"
setAdministrations	setAdministrations
setAdministrations-method	setAdministrations
setArm	setArm
setArm-method	setArm
setArms	Set the arms of an object.
setArms-method	Set the arms of an object.
setcError	Set the parameter c.
setcError-method	Set the parameter c.
setContent	Set content of a library of models.
setContent-method	Set content of a library of models.
setDerivatives	Set the derivatives of the model error equation.
setDerivatives-method	Set the derivatives of the model error equation.
setDescription	Set the description of a model.
setDescription-method	Set the description of a model.
setDesigns	Set the designs.
setDesigns-method	Set the designs.
setDistribution	Set the distribution.
setDistribution-method	Set the distribution.
setDose	Set the amount of dose
setDose-method	Set the amount of dose
setEquation	Set the equation of a model error.
setEquation-method	Set the equation of a model error.
setEquations	Set the equations of a model.
setEquations-method	Set the equations of a model.
setEquationsAfterInfusion	Set the equations after infusion.
setEquationsAfterInfusion-method	Set the equations after infusion.
setEquationsDuringInfusion	Set the equations during infusion.
setEquationsDuringInfusion-method	Set the equations during infusion.
setEvaluationFIMResults	Set the evaluation results.
setEvaluationFIMResults-method	Set the evaluation results.
setEvaluationInitialDesignResults	Set the evaluation results of the initial design.
setEvaluationInitialDesignResults-method	Set the evaluation results of the initial design.
setFim	setFim
setFim-method	setFim
setFimTypeToString	Convert the type of the object fim to a string.
setFimTypeToString-method	Convert the type of the object fim to a string.
setFisherMatrix	Set the FIM.
setFisherMatrix-method	Set the FIM.
setFixedEffects	Set the fixed effects.
setFixedEffects-method	Set the fixed effects.
setFixedMu	Set the mu as fixed or not.
setFixedMu-method	Set the mu as fixed or not.
setFixedOmega	Set the omega as fixed of not.
setFixedOmega-method	Set the omega as fixed of not.
setInitialConditions	setInitialConditions
setInitialConditions-method	setInitialConditions
setIterationAndCriteria	Set the iteration with the convergence criteria.
setIterationAndCriteria-method	Set the iteration with the convergence criteria.
setModel	Set the model.
setModel-method	Set the model.
setModelError	Set the model error.
setModelError-method	Set the model error.
setModelFromLibrary	Set a model from the library of model
setModelFromLibrary-method	Set a model from the library of model
setMu	Set the value of the fixed effect mu of an object.
setMu-method	Set the value of the fixed effect mu of an object.
setName	Set the name of an object.
setName-method	Set the name of an object.
setNumberOfArms	setNumberOfArms
setNumberOfArms-method	setNumberOfArms
setOdeSolverParameters	Set the parameters of the ode solver.
setOdeSolverParameters-method	Set the parameters of the ode solver.
setOmega	Set the matrix omega of an object.
setOmega-method	Set the matrix omega of an object.
setOptimalDesign	Set the optimal design.
setOptimalDesign-method	Set the optimal design.
setOptimalWeights	Set the optimal weights.
setOptimalWeights-method	Set the optimal weights.
setOptimizationResults	Set the optimization results.
setOptimizationResults-method	Set the optimization results.
setOutcome	setOutcome
setOutcome-method	setOutcome
setOutcomes	Set the outcomes of a model.
setOutcomes-method	Set the outcomes of a model.
setOutcomesEvaluation	setOutcomesEvaluation
setOutcomesEvaluation-method	setOutcomesEvaluation
setOutcomesForEvaluation	Set the outcomes of a model used for the evaluation (is scales outcomes).
setOutcomesForEvaluation-method	Set the outcomes of a model used for the evaluation (is scales outcomes).
setOutcomesGradient	setOutcomesGradient
setOutcomesGradient-method	setOutcomesGradient
setParameters	Set the parameters of an object.
setParameters-method	Set the parameters of an object.
setSamplingConstraintForOptimization	setSamplingConstraintForOptimization
setSamplingConstraintForOptimization-method	setSamplingConstraintForOptimization
setSamplings	Set the sampling times.
setSamplings-method	Set the sampling times.
setSamplingTime	setSamplingTime
setSamplingTime-method	setSamplingTime
setSamplingTimes	setSamplingTimes
setSamplingTimes-method	setSamplingTimes
setSamplingTimesConstraints	setSamplingTimesConstraints
setSamplingTimesConstraints-method	setSamplingTimesConstraints
setShrinkage	Set the shrinkage.
setShrinkage-method	Set the shrinkage.
setSigmaInter	Set the parameter sigma inter.
setSigmaInter-method	Set the parameter sigma inter.
setSigmaSlope	Set the parameter sigma slope.
setSigmaSlope-method	Set the parameter sigma slope.
setSize	setSize
setSize-method	setSize
setTau	setTau
setTau-method	setTau
setTimeDose	setTimeDose
setTimeDose-method	setTimeDose
setTinf	Set the infusion duration.
setTinf-method	Set the infusion duration.
setVarianceEffects	Set the matrix of the variance effects.
setVarianceEffects-method	Set the matrix of the variance effects.
show-method	show
SimplexAlgorithm	Class "SimplexAlgorithm"
SimplexAlgorithm-class	Class "SimplexAlgorithm"

-- misc --

_PACKAGE

Fisher Information matrix for design evaluation/optimization for nonlinear mixed effects models.