calc_worst_type_I_error {OptimalGoldstandardDesigns}

Helper function to calculate the maximal probability of rejecting the non-inferiority hypothesis in the testing procedure featuring nonsequential futility, given a point hypothesis for the superiority hypothesis.

Description

This is required in designs with nonsequential futility testing, as choosing locally valid designs is insufficient to gurantee type I error control.

Usage

calc_worst_type_I_error(bTC2e, D)

Arguments

bTC2e

second stage critical value for the TC testing problem.

D

list containing all parameters of a the trial design.