plotIsomeans {ORCME}

Plot of the observed gene expression and the isotonic means with respect to dose

Description

The function is plotting the observed data points of the gene expression and isotonic means with respect to dose for one particular gene.

Usage

plotIsomeans(monoData, obsData, doseData, geneIndex)

Arguments

monoData

isotonic means with respect to dose for all genes

obsData

observed gene expression for all genes

doseData

indicates the dose levels

geneIndex

index of the gene to be plotted

Value

Plot of the data points and the isotonic means for each dose with the isotonic regression curve.

Author(s)

Adetayo Kasim, Martin Otava and Tobias Verbeke

References

Lin D., Shkedy Z., Yekutieli D., Amaratunga D., and Bijnens, L. (editors). (2012) Modeling Dose-response Microarray Data in Early Drug Development Experiments Using R. Springer.

Cheng, Y. and Church, G. M. (2000). Biclustering of expression data. In: Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology, 1, 93-103.

See Also

ORCME, monotoneDirection

Examples

  data(doseData)
  data(geneData)

  dirData <- monotoneDirection(geneData = geneData,doseData = doseData)
  incData <- as.data.frame(dirData$incData)
  obsIncData <- as.data.frame(dirData$obsincData)
  
  ## gene-specific profile plot
  plotIsomeans(monoData=incData,obsData=obsIncData,doseData=
  doseData,geneIndex=10)