tblNCA {NonCompart}

Table output NCA

Description

Do multiple NCA and returns a result table. See sNCA for more detail i.e. iAUC

Usage

tblNCA(concData, key = "Subject", colTime = "Time", colConc = "conc", dose = 0, 
       adm = "Extravascular", dur = 0, doseUnit = "mg", timeUnit = "h", 
       concUnit = "ug/L", down = "Linear", R2ADJ = 0, MW = 0, SS = FALSE, 
       iAUC = "", excludeDelta = 1)

Arguments

concData

concentration data table

key

column names of concData to be shown in the output table

colTime

column name for time

colConc

column name for concentration

dose

administered dose

adm

one of "Bolus" or "Infusion" or "Extravascular" to indicate drug administration mode

dur

duration of infusion

doseUnit

unit of dose

timeUnit

unit of time

concUnit

unit of concentration

down

method to calculate AUC, "Linear" or "Log"

R2ADJ

Lowest threshold of adjusted R-square value to do manual slope determination

MW

molecular weight of drug

SS

if steady-state, this should be TRUE. AUCLST (AUClast) is used instead of AUCIFO (AUCinf) for the calculation of Vz (VZFO, VZO), CL (CLFO, CLO), and Vdss (VSSO).

iAUC

data.frame for interval AUC

excludeDelta

Improvement of R2ADJ larger than this value could exclude the last point. Default value 1 is for the compatibility with other software.

Details

Tabular output of NCA with many subjects. Author recommends to use excludeDelta option with about 0.3.

Value

Basically same with sNCA

Author(s)

Kyun-Seop Bae <[e-mail]>

See Also

help, sNCA

Examples

tblNCA(Theoph, key="Subject", dose=320, concUnit="mg/L")
tblNCA(Indometh, key="Subject", colTime="time", colConc="conc", dose=25, 
       adm="Infusion", dur=0.5, concUnit="mg/L")