VaccineData {NPP}

Dataset of a Vaccine Trial for RotaTeq and Multiple Historical Trials for Control Group

Description

The study was designed to investigate the concomitant use of RotaTeq(Test Vaccine) and some routine pediatric vaccines between 2001-2005. The dataset includes four historical control trials. The purpose of the study is to borrow the historical controls for the non-inferiority trial. The interest is in the response rate to the routine vaccines.

Usage

data("VaccineData")

Format

A data frame with 6 observations on the following 7 variables.

Data.Time

indicator of historical data (coded as 0) or current data (coded as 1).

StudyID

character to distinguish different studies.

Group

indicator of control group (coded as 0) or treatment group (coded as 1).

Start.Year

start year of the trial

End.Year

end year of the trial

N

total number of patients enrolled and dosed in the group

y

total number of patients respond to the vaccine

References

Liu, G.F. (2018). A Dynamic Power Prior for Borrowing Historical Data in Noninferiority Trials with Binary Endpoint. Pharmaceutical Statistics 17:61-73.

Examples

data(VaccineData)