NPHMC {NPHMC}

Title

Description

Title

Usage

NPHMC(
  n = NULL,
  power = 0.8,
  alpha = 0.05,
  accrualtime = NULL,
  followuptime = NULL,
  p = 0.5,
  accrualdist = c("uniform", "increasing", "decreasing"),
  hazardratio = NULL,
  oddsratio = NULL,
  pi0 = NULL,
  survdist = c("exp", "weib"),
  k = 1,
  lambda0 = NULL,
  data = NULL
)

Arguments

n

sample size needed for power calculation

power

powered needed for sample size calculation

alpha

level of significance of statistical test (default is 0.05)

accrualtime

level of accrual period

followuptime

length of follow up time

p

proportion of subjects in treatment arm (default is 0.5)

accrualdist

accrual pattern (uniform, decreasing, increasing)

hazardratio

hazard ratio of uncured patients between two arms (must be greater than 0)

oddsratio

odds ratio of cured patients between two arms. It must be greater than 0. If it is 0, the model is reduced to standard proportional hazards model.

pi0

cure rate for the control arm (between 0 and 1)

survdist

distribution of uncured patients (exp or weib)

k

shape parameter if survdist = 'weib' (By default, it is 1 referrring to exponential distribution)

lambda0

scale parameter of exponential or Weibull distribution for survival times of uncured patients in the control arm.

data

observed or historical data if available

Value

a NPHMC object

Examples

NPHMC(power=0.90,alpha=0.05,accrualtime=3,followuptime=4,p=0.5,accrualdist="uniform",
hazardratio=2/2.5,oddsratio=2.25,pi0=0.1,survdist="exp",k=1,lambda0=0.5)
data(e1684szdata)
NPHMC(power=0.80,alpha=0.05,accrualtime=4,followuptime=3,p=0.5,accrualdist="uniform",
     data=e1684szdata)
n=seq(100, 500, by=50)
NPHMC(n=n, alpha=0.05,accrualtime=3,followuptime=4,p=0.5,
     accrualdist="uniform", hazardratio=2/2.5,oddsratio=2.25,pi0=0.1,survdist="exp",
     k=1,lambda0=0.5)
n=seq(100, 500, by=50)
NPHMC(n=n,alpha=0.05,accrualtime=4,followuptime=3,p=0.5,
     accrualdist="uniform",data=e1684szdata)