NNTbiomarker-package {NNTbiomarker}

Plan a biomarker validation study by focusing on desired clinical actionability.

Description

Clarifying what performance would suffice if the test is to improve medical care makes it possible to design meaningful validation studies.

Details

Package:	NNTbiomarker
Type:	Package
Version:	0.1
Date:	2015-03-21
License:	What license is it under?

This package bases the design of a biomarker study on the idea of "number needed to treat" (NNT). It postulates a "range of discomfort" for NNT, within which the clinical decision is uncomfortable for a treating physician. provides a shiny window for eliciting the boundaries of the range of number needed to

Author(s)

Roger Day

Maintainer: Roger Day <[e-mail]>

References

See author for unpublished manuscript.

Examples

NNT.to.pv(NNTpos=5, NNTneg=28)
NNT.from.sesp(se=0.7, sp=0.9, prev=0.1)
pv.to.sesp(pv = cbind(ppv=seq(.5, .9, .1), npv=0.9), prev = 0.2)