NBDesign-package {NBDesign}

Design and Monitoring of Clinical Trials with Negative Binomial Endpoint

Description

Calculate various functions needed for design and monitoring clinical trials with negative binomial endpoint with variable follow-up. This version has a few changes compared to the previous version 1.0.0, including (1) correct a typo in Type 1 censoring, mtbnull=bnull and (2) restructure the code to account for shape parameter equal to zero, i.e. Poisson scenario.

Details

The DESCRIPTION file:

Package:	NBDesign
Type:	Package
Version:	2.0.0
Date:	2020-09-09
Title:	Design and Monitoring of Clinical Trials with Negative Binomial Endpoint
Description:	Calculate various functions needed for design and monitoring clinical trials with negative binomial endpoint with variable follow-up. This version has a few changes compared to the previous version 1.0.0, including (1) correct a typo in Type 1 censoring, mtbnull=bnull and (2) restructure the code to account for shape parameter equal to zero, i.e. Poisson scenario.
Authors@R:	c( person(given="Xiaodong", family="Luo", email = "[e-mail]", role =c("aut", "cre")), person("Sanofi", role = "cph"))
Depends:	R (>= 3.1.2)
Imports:	stats,PWEALL,MASS
License:	GPL (>= 2)
RoxygenNote:	5.0.1
LazyData:	true
Author:	Xiaodong Luo [aut, cre], Sanofi [cph]
Maintainer:	Xiaodong Luo <[e-mail]>

Index of help topics:

NBDesign-package        Design and Monitoring of Clinical Trials with
                        Negative Binomial Endpoint
negint2                 A utility functon to calculate the mean
                        exposure under different scenarios
ynegbinompower          Two-sample sample size calculation for negative
                        binomial distribution with variable follow-up
ynegbinompowersim       Two-sample sample size calculation for negative
                        binomial distribution with variable follow-up
ynegbinomsize           Two-sample sample size calculation for negative
                        binomial distribution with variable follow-up

Author(s)

NA

Maintainer: NA