normalize_timecourse {MultIS}

Normalizes a time course using a given mapping from integration sites to clones.

Description

Each integration site is replaced by its clone. The size of the clone is adjusted to be the mean size of the integration sites within it. For integration sites that are not mentioned in 'rec', we adjust by the average number of integration sites per clone.

Usage

normalize_timecourse(readouts, rec, rec_first = FALSE, reduce_clones = TRUE)

Arguments

readouts

The integration site readouts to adjust.

rec

A matrix with columns "IS" and "Clone" that assigns each integration site to a clone.

rec_first

Whether the clones should be put in the first rows of the resulting time course.

reduce_clones

Whether to represent the integration sites by their respective clone.

Value

The adjusted time course.